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Research Library#

Deep scientific and clinical research on dermatitis herpetiformis. These documents cover immunology, genetics, clinical trials, and emerging therapies — all fully cited from peer-reviewed sources.

Medical Disclaimer

This is a research reference, not medical advice. Read the full disclaimer.

Core Science#

Pathogenesis & Immunology#

The complete immunological cascade from gluten ingestion to skin blisters. Covers TG2/TG3 distinction, epitope spreading, the gut-skin axis, complement activation, neutrophil recruitment, cytokine networks, and dapsone's mechanism of action.

Epidemiology & Diagnosis#

Incidence and prevalence data worldwide, demographics, clinical presentation, the diagnostic algorithm (DIF biopsy, serology), differential diagnosis, associated conditions, natural history, and quality of life impact.

Genetics & Genomics#

HLA-DQ2/DQ8 associations, non-HLA GWAS loci, TGM3 gene analysis, epigenetic factors, gene expression in DH skin, pharmacogenomics of dapsone, population genetics, and Mendelian randomization evidence.

Treatment & Trials#

Treatments & Clinical Trials#

Current standard of care (dapsone + GFD), alternative medications, biologics and JAK inhibitors, the celiac disease drug pipeline (25+ compounds), microbiome interventions, and long-term prognosis.

Emerging Research#

20 cutting-edge directions: CRISPR gene editing, oral tolerance induction, nanoparticle therapies, CAR-T for autoimmunity, Treg therapy, gluten-degrading enzymes, helminth therapy, vagus nerve stimulation, IgA-specific therapies, CRISPR-edited wheat, and more.

Monitoring#

Monitoring & Neurological Comorbidities#

Serological monitoring on GFD, antibody response timelines, disease tracking biomarkers, and neurological conditions associated with celiac disease and DH.